When standard treatments haven’t helped — there are still options.
Treatment-resistant depression (TRD) is a type of major depressive disorder that doesn’t improve after trying at least two different antidepressant medications, at full dosage and for a sufficient duration. It’s a clinical diagnosis, but it also reflects a deeply personal journey — one marked by persistence, frustration, and continued hope.
Many people with TRD have done everything asked of them: they’ve stayed consistent with therapy, followed medication plans, and sought help when symptoms persisted. Still, they haven’t found lasting relief. That’s not a failure — it’s a sign that a different type of treatment may be needed.
TRD is more common than many realize. It’s estimated that up to one-third of people with depression may not respond to traditional care alone.
While TRD is formally diagnosed by a clinician, some common signs that you may be experiencing treatment-resistant depression include:
If any of these sound familiar, you’re not alone — and you may benefit from exploring options specifically designed for TRD.
There isn’t one single cause of treatment-resistant depression. Each person’s experience with depression is shaped by a unique mix of biology, life history, and underlying health factors.
Some reasons why standard treatments may not work include:
The key message: TRD isn’t your fault. It means your depression may require a more targeted or advanced approach.
If traditional treatments haven’t worked, there are advanced therapies backed by clinical research — and designed for cases just like yours. Lumora connects patients to trusted partner clinics offering these FDA-cleared options in safe, supportive environments.
Non-invasive brain stimulation that targets deeper structures.
TMS is a next-generation form of TMS therapy. It uses a specialized H-coil to reach broader and deeper areas of the brain associated with mood regulation — areas that standard TMS may not fully access.
TMS offers a non-medication path forward — one that’s been life-changing for many people with TRD.
Fast-acting support for stubborn symptoms.
IV ketamine works on a different set of brain receptors than traditional antidepressants. For some individuals with TRD, it provides rapid symptom relief, often within hours or days.
FDA-approved specifically for treatment-resistant depression.
SPRAVATO® is a prescription nasal spray derived from ketamine and approved for adults with TRD. It’s used alongside a daily oral antidepressant and administered in a clinical setting.
Offers a structured, evidence-based protocol for TRD
Exploring advanced care can feel like a big step — but it doesn’t have to be overwhelming. Lumora helps you move forward with clarity and support at every stage.
Here’s what the process usually looks like:
We’re not a clinic, but we work closely with the ones we trust — to make sure your experience is safe, supported, and centered on your well-being.
Is Advanced Treatment Right for You?
You may be a good candidate for TMS, ketamine therapy, or SPRAVATO® if:
Lumora exists to help patients in this exact situation — people looking for next steps, not dead ends.
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